期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 76, 期 21, 页码 4275-4289出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03222-1
关键词
PVT1; MYC; Gene fusion; Positive feedback; Promoter; Enhancer
资金
- National Natural Science Foundation of China [81572787, 81672683, 81672993, 81772928, 81872278]
- Overseas Expertise Introduction Project for Discipline Innovation (111 Project) [111-2-12]
- Natural Science Foundation of Hunan Province [2016JC2035, 2017SK2105, 2018JJ3704, 2018JJ3815, 2018SK21210, 2018SK21211, 2019JJ50354]
Numerous studies have shown that non-coding RNAs play crucial roles in the development and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly encodes a long non-coding RNA (lncRNA) and is located on chromosome 8q24.21, which constitutes a fragile site for genetic aberrations. PVT1 is well-known for its interaction with its neighbor MYC, which is a qualified oncogene that plays a vital role in tumorigenesis. In the past several decades, increasing attention has been paid to the interaction mechanism between PVT1 and MYC, which will benefit the clinical treatment and prognosis of patients. In this review, we summarize the coamplification of PVT1 and MYC in cancer, the positive feedback mechanism, and the latest promoter competition mechanism of PVT1 and MYC, as well as how PVT1 participates in the downstream signaling pathway of c-Myc by regulating key molecules. We also briefly describe the treatment prospects and research directions of PVT1 and MYC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据