期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 76, 期 20, 页码 3917-3937出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03190-6
关键词
Fecal microbiota transplantation; Innate and adaptive immune cells; Germ-free animals
资金
- National Natural Science Foundation of China [31420103908]
- National Key R&D Program of China [2017YFD0500506]
- European Union [633531]
The gastrointestinal tract is the site of nutrient digestion and absorption and is also colonized by diverse, highly mutualistic microbes. The intestinal microbiota has diverse effects on the development and function of the gut-specific immune system, and provides some protection from infectious pathogens. However, interactions between intestinal immunity and microorganisms are very complex, and recent studies have revealed that this intimate crosstalk may depend on the production and sensing abilities of multiple bioactive small molecule metabolites originating from direct produced by the gut microbiota or by the metabolism of dietary components. Here, we review the interplay between the host immune system and the microbiota, how commensal bacteria regulate the production of metabolites, and how these microbiota-derived products influence the function of several major innate and adaptive immune cells involved in modulating host immune homeostasis.
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