期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 76, 期 22, 页码 4511-4524出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03231-0
关键词
Nucleolus; Cancer; Pol I; rRNA; Ribosome
资金
- VA [DC BX003374]
- NCI/NIH [CA194048]
- Predoctoral Training in Cell and Molecular Biology [T32GM008111]
The nucleolus is a sub-nuclear body known primarily for its role in ribosome biogenesis. Increased number and/or size of nucleoli have historically been used by pathologists as a prognostic indicator of cancerous lesions. This increase in nucleolar number and/or size is classically attributed to the increased need for protein synthesis in cancer cells. However, evidences suggest that the nucleolus plays critical roles in many cellular functions in both normal cell biology and disease pathologies, including cancer. As new functions of the nucleolus are elucidated, there is mounting evidence to support the role of the nucleolus in regulating additional cellular functions, particularly response to cellular stressors, maintenance of genome stability, and DNA damage repair, as well as the regulation of gene expression and biogenesis of several ribonucleoproteins. This review highlights the central role of the nucleolus in carcinogenesis and cancer progression and discusses how cancer cells may become addicted to nucleolar functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据