期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 76, 期 19, 页码 3711-3722出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03161-x
关键词
Autophagy; Protein methylation; Non-histone protein methylation; Histone methylation; Methyltransferase; Demethylase; Posttranslational modification; Autophagy-related proteins
资金
- National Natural Science Foundation of China [81600188, 81670050]
- Tongji Hospital Fund for Distinguished Young Scholars [2016YQ02]
- Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College, HUST
Studies over the past decades have elucidated the critical role of autophagy in human health and diseases. Although the processes of autophagy in the cytoplasm have been well studied, the posttranscriptional and epigenetic regulation mechanisms of autophagy are still poorly understood. Protein methylation, including histone methylation and non-histone protein methylation, is the most important type of posttranscriptional and epigenetic modification. Recent studies have shown that protein methylation is associated with effects on autophagosome formation, autophagy-related protein expression, and signaling pathway activation, but the details are still unclear. Thus, it is important to summarize the current status and discuss the future directions of research on protein methylation in the context of autophagy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据