期刊
CELL STEM CELL
卷 24, 期 6, 页码 860-876出版社
CELL PRESS
DOI: 10.1016/j.stem.2019.05.005
关键词
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资金
- Swiss National Science Foundation [310030_179447]
- Ecole Polytechnique Federale de Lausanne (EPFL)
- European Union's Horizon 2020 Research and Innovation Programme (INTENS) [668294]
- Personalized Health and Related Technologies Initiative from the ETH Board
- National Center of Competence in Research (NCCR) Bio-Inspired Materials
- FreeNovation funding program of the Novartis Research Foundation
- Marie Sklodowska-Curie European Training Network EUROoC (H2020-MSCA-ITN-2018)
- Vienna Science and Technology Fund (WWTF)
- Swiss National Science Foundation (SNF) [310030_179447] Funding Source: Swiss National Science Foundation (SNF)
- H2020 Societal Challenges Programme [668294] Funding Source: H2020 Societal Challenges Programme
Organoids form through self-organization processes in which initially homogeneous populations of stem cells spontaneously break symmetry and undergo in-vivo-like pattern formation and morphogenesis, though the processes controlling this are poorly characterized. While these in vitro self-organized tissues far exceed the microscopic and functional complexity obtained by current tissue engineering technologies, they are non-physiological in shape and size and have limited function and lifespan. Here, we discuss how engineering efforts for guiding stem-cell-based development at multiple stages can form the basis for the assembly of highly complex and rationally designed self-organizing multicellular systems with increased robustness and physiological relevance.
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