相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Global prediction of primary liver cancer incidences and mortality in 2040
Chenxi Li et al.
JOURNAL OF HEPATOLOGY (2023)
Drug repurposing: progress, challenges and recommendations
Sudeep Pushpakom et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
Mario Mauthe et al.
AUTOPHAGY (2018)
The Unfolded Protein Response and Cell Fate Control
Claudio Hetz et al.
MOLECULAR CELL (2018)
Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis
Mikael S. Lindstrom et al.
ONCOGENE (2018)
Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells
Yongjie Zhang et al.
FRONTIERS IN PHARMACOLOGY (2018)
Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy
Mitchell G. Lawrence et al.
EUROPEAN UROLOGY (2018)
Ribosome biogenesis in cancer: new players and therapeutic avenues
Joffrey Pelletier et al.
NATURE REVIEWS CANCER (2018)
Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine
Yongjie Zhang et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2017)
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
Zdenek Skrott et al.
NATURE (2017)
A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress
Peter M. Bruno et al.
NATURE MEDICINE (2017)
Lysosomotropism depends on glucose: a chloroquine resistance mechanism
Laura E. Gallagher et al.
CELL DEATH & DISEASE (2017)
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Hong Xu et al.
NATURE COMMUNICATIONS (2017)
A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription
Chelsea Herdman et al.
PLOS GENETICS (2017)
Ribosomal DNA copy number amplification and loss in human cancers is linked to tumor genetic context, nucleolus activity, and proliferation
Meng Wang et al.
PLOS GENETICS (2017)
Repurposing Drugs in Oncology (ReDO)-chloroquine and hydroxychloroquine as anti-cancer agents
Ciska Verbaanderd et al.
ECANCERMEDICALSCIENCE (2017)
Targeting RNA-Polymerase I in Both Chemosensitive and Chemoresistant Populations in Epithelial Ovarian Cancer
Robert Cornelison et al.
CLINICAL CANCER RESEARCH (2017)
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population
Nadine Hein et al.
BLOOD (2017)
Autophagy inhibitors
Benoit Pasquier
CELLULAR AND MOLECULAR LIFE SCIENCES (2016)
Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells
M. A. King et al.
ONCOGENE (2016)
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
Jaclyn Quin et al.
ONCOTARGET (2016)
ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition
Shane M. Harding et al.
CELL REPORTS (2015)
RNA helicase DDX21 coordinates transcription and ribosomal RNA processing
Eliezer Calo et al.
NATURE (2015)
Targeting RNA polymerase I to treat MYC-driven cancer
G. Poortinga et al.
ONCOGENE (2015)
Tumor Vessel Normalization by Chloroquine Independent of Autophagy
Hannelore Maes et al.
CANCER CELL (2014)
A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity
Karita Peltonen et al.
CANCER CELL (2014)
Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway
Lucia Morgado-Palacin et al.
CARCINOGENESIS (2014)
Involvement of Myeloperoxidase and NADPH Oxidase in the Covalent Binding of Amodiaquine and Clozapine to Neutrophils: Implications for Drug-Induced Agranulocytosis
Alexandra R. Lobach et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2014)
Small Molecule BMH-Compounds That Inhibit RNA Polymerase I and Cause Nucleolar Stress
Karita Peltonen et al.
MOLECULAR CANCER THERAPEUTICS (2014)
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
Dorthe H. Larsen et al.
NATURE CELL BIOLOGY (2014)
Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells
Ilmin Kwon et al.
SCIENCE (2014)
DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response
Laureen Colis et al.
ONCOTARGET (2014)
The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death
Shuxi Qiao et al.
AUTOPHAGY (2013)
The shared genomic architecture of human nucleolar organizer regions
Ioanna Floutsakou et al.
GENOME RESEARCH (2013)
Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53
Megan J. Bywater et al.
CANCER CELL (2012)
Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency
Quentin McAfee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer
Denis Drygin et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2010)
Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels
Kaspar Burger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The Nucleolus under Stress
Severine Boulon et al.
MOLECULAR CELL (2010)
Identification of Novel p53 Pathway Activating Small-Molecule Compounds Reveals Unexpected Similarities with Known Therapeutic Agents
Karita Peltonen et al.
PLOS ONE (2010)
Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice
Shinji Shimizu et al.
ARCHIVES OF TOXICOLOGY (2009)
ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
Gabriela Bindea et al.
BIOINFORMATICS (2009)
What the nucleolus says to a tumour pathologist
Massimo Derenzini et al.
HISTOPATHOLOGY (2009)
Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway
H. F. Horn et al.
ONCOGENE (2008)
Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells
Walter M. A. Westerink et al.
TOXICOLOGY IN VITRO (2007)
Topoisomerase IIβ-Mediated DNA double-strand breaks:: Implications in doxorubicin cardiotoxicity and prevention by dexrazoxane
Yi Lisa Lyu et al.
CANCER RESEARCH (2007)
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks
Michael Kruhlak et al.
NATURE (2007)
The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
Justin Lamb et al.
SCIENCE (2006)
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Anne E. Carpenter et al.
GENOME BIOLOGY (2006)
Examination of 209 drugs for inhibition of cytochrome p450 2C8
RL Walsky et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2005)
mTOR-dependent activation of the transcription factor TIMA links rRNA synthesis to nutrient availability
C Mayer et al.
GENES & DEVELOPMENT (2004)
A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity
WC Tse et al.
ACCOUNTS OF CHEMICAL RESEARCH (2004)
ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth
J Zhao et al.
MOLECULAR CELL (2003)
High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter
TA Sohn et al.
CARCINOGENESIS (2002)
Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8:: A new high affinity and turnover enzyme-specific probe substrate
XQ Li et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Inhibition of cytochromes P450 by antifungal imidazole derivatives
WJ Zhang et al.
DRUG METABOLISM AND DISPOSITION (2002)
Formation of a complex between nucleolin and replication protein a after cell stress prevents initiation of DNA replication
Y Daniely et al.
JOURNAL OF CELL BIOLOGY (2000)
分享论文
