期刊
CELL
卷 178, 期 3, 页码 672-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2019.05.048
关键词
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资金
- Princeton Neuroscience Institute's Innovation Award
- CV Starr Fellowship
- Brain and Behavior Research Foundation's NARSAD Young Investigator Award
- Foundation for Prader-Willi Research
- American Diabetes Association Pathway
- American Diabetes Association Core Program
- JPB Foundation
- Robertson Therapeutic Development Fund
Homeostatic control of core body temperature is essential for survival. Temperature is sensed by specific neurons, in turn eliciting both behavioral (i.e., locomotion) and physiologic (i.e., thermogenesis, vasodilatation) responses. Here, we report that a population of GABAergic (Vgat-expressing) neurons in the dorsolateral portion of the dorsal raphe nucleus (DRN), hereafter DRNVgat neurons, are activated by ambient heat and bidirectionally regulate energy expenditure through changes in both thermogenesis and locomotion. We find that DRNVgat neurons innervate brown fat via a descending projection to the raphe pallidus (RPa). These neurons also densely innervate ascending targets implicated in the central regulation of energy expenditure, including the hypothalamus and extended amygdala. Optogenetic stimulation of different projection targets reveals that DRNVgat neurons are capable of regulating thermogenesis through both a direct descending pathway through the RPa and multiple indirect ascending pathways. This work establishes a key regulatory role for DRNVgat neurons in controlling energy expenditure.
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