期刊
CELL
卷 177, 期 7, 页码 1814-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2019.04.029
关键词
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资金
- NIH Office of Research Infrastructure Programs [P40 OD010440]
- Eldee Foundation
- Bloomfield family of Montreal
- Allen Discovery Center (Paul G. Allen Frontiers Group)
- Adelis Foundation [0604916191]
- ERC [335624]
- European Research Council (ERC) [335624] Funding Source: European Research Council (ERC)
It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis elegans nematodes, parental responses can transmit heritable small RNAs that regulate gene expression trans-generationally. In this study, we show that a neuronal process can impact the next generations. Neurons-specific synthesis of RDE-4-dependent small RNAs regulates germline amplified endogenous small interfering RNAs (siRNAs) and germline gene expression for multiple generations. Further, the production of small RNAs in neurons controls the chemotaxis behavior of the progeny for at least three generations via the germline Argonaute HRDE-1. Among the targets of these small RNAs, we identified the conserved gene saeg-2, which is transgenerationally downregulated in the germline. Silencing of saeg-2 following neuronal small RNA biogenesis is required for chemotaxis under stress. Thus, we propose a small-RNA-based mechanism for communication of neuronal processes transgenerationally.
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