期刊
CARBOHYDRATE POLYMERS
卷 213, 期 -, 页码 1-9出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.02.016
关键词
Chitosan; Nanoparticle; Staphylococcus spp.; Biofilm; Bovine mastitis
资金
- Universidad Nacional de Villa Maria
- National Agency for Science and Technology Promotion [PICT 2012-2696]
- National Scientific and Technical Research Council (CONICET) - Argentina [203-201501-00009]
- CONICET
Staphylococcus is the most commonly isolated genus from animals with intramammary infections, and mastitis is the most prevalent disease that affects dairy cows in many countries. These pathogens can live in biofilms, a self-produced matrix, which allow them evade the innate immune system and the antibiotic therapy, thereby producing persistent infections. The aim of this study was to explore the antimicrobial potential of chitosan nanoparticles (Ch-NPs) obtained by the reverse micellar method. We found that the nanoformulation developed presents antimicrobial activity against mastitis pathogens in a dose-dependent manner. Moreover, different experiments corroborated that the antimicrobial effectiveness of Ch-NP was greater than that shown by the native polymer used in the preparation of these nanocomposites. Ch-NPs caused membrane damage to bacterial cells and inhibited bacterial biofilm formation, without affecting the viability of bovine cells. These findings show the great potential of Ch-NPs as therapeutic agent for bovine mastitis treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据