期刊
CANCER SCIENCE
卷 110, 期 8, 页码 2485-2492出版社
WILEY
DOI: 10.1111/cas.14121
关键词
inhalation toxicity; intra-tracheal intra-pulmonary spraying; malignant mesothelioma; MWCNT-7; rat
类别
资金
- 5th Term Long-Range Research Initiative (2017) by Japan Chemical Industry Association
- Ministry of Health, Labour and Welfare [H22-kagaku-ippan-005, H22-kagaku-shitei-004, H25-kagaku-ippan-004, H27-kagaku-shitei-004, H28-kagaku-ippan-004]
- Egyptian Cultural Affairs and Missions Sector
Multi-walled carbon nanotube-7 (MWCNT-7) fibers are biopersistent and have a structure similar to asbestos. MWCNT-7 has been shown to induce malignant mesothelioma when administered by intrascrotal or intraperitoneal injection in rats and mice, and an inhalation study demonstrated that rats exposed to respirable MWCNT-7 developed lung tumors. MWCNT-N, which is similar to MWCNT-7, was shown to induce both lung tumors and malignant mesothelioma in rats when administered by trans-tracheal intrapulmonary spraying (TIPS). The present study was performed to investigate the carcinogenicity of MWCNT-7 when administered by the TIPS method. Ten-week-old male F344/Crj rats were divided into 3 groups and administered 0.5 mL vehicle, 0.250 mu g/mL MWCNT-7 or 0.250 mu g/mL crocidolite once a week for 12 weeks (total doses of 1.5 mg/rat) and then observed for up to 104 weeks. Rats in the MWCNT-7 group began to die from pathologies associated with the development of malignant mesothelioma 35 weeks after the final TIPS administration. Overall, the incidence of malignant mesothelioma in the MWCNT-7 group was significantly higher than in the vehicle or crocidolite groups.
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