期刊
CANCER LETTERS
卷 452, 期 -, 页码 71-78出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2019.03.007
关键词
Lipids; Breastfeeding; Maternal BMI; Pre-B ALL; t(12;21) translocation
类别
资金
- National Institute for Environmental Health Sciences at the National Institutes of Health [P01 ES018172, P50 ES018172, U2C ES026561]
- United States Environmental Protection Agency [RD83615901, RD83451101]
- Children with Cancer U.K.
- Environment and Health Fund, Israel
- Swedish Heart-Lung Foundation [20170736, 20170603]
Early-life exposures are believed to influence the incidence of pediatric acute lymphoblastic leukemia (ALL). Archived neonatal blood spots (NBS), collected within the first days of life, offer a means to investigate small molecules that reflect early-life exposures. Using untargeted metabolomics, we compared abundances of small-molecule features in extracts of NBS punches from 332 children that later developed ALL and 324 healthy controls. Subjects were stratified by early (1-5 y) and late (6-14 y) diagnosis. Mutually-exclusive sets of metabolic features - representing putative lipids and fatty acids - were associated with ALL, including 9 and 19 metabolites in the early- and late-diagnosis groups, respectively. In the late-diagnosis group, a prominent cluster of features with apparent 18:2 fatty-acid chains suggested that newborn exposure to the essential nutrient, linoleic acid, increased ALL risk. Interestingly, abundances of these putative 18:2 lipids were greater in infants who were fed formula rather than breast milk (colostrum) and increased with the mother's pre-pregnancy body mass index. These results suggest possible etiologic roles of newborn nutrition in late-diagnosis ALL.
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