期刊
CANCER LETTERS
卷 455, 期 -, 页码 26-35出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2019.04.019
关键词
NPC; FOXO3a; Radioresistance; Epithelial-mesenchymal transition; Wnt
类别
资金
- National Natural Science Foundation of China [81572960, 81773231]
Mutations in the forkhead box O 3a (FOXO3a) gene are closely related to the progression of several types of cancers. However, few studies explore the relationship between FOXO3a and nasopharyngeal carcinoma (NPC). Our findings demonstrate that silencing FOXO3a promotes tumor radioresistance of NPC in vitro and in vivo through inducing EMT and activating Wnt/beta-catenin signal pathway. These data establish that FOXO3a can be a novel and reliable NPC marker and a potential therapeutic target against NPC.
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