期刊
CANCER IMMUNOLOGY IMMUNOTHERAPY
卷 68, 期 7, 页码 1157-1169出版社
SPRINGER
DOI: 10.1007/s00262-019-02349-1
关键词
Skull base chordoma; TIM3; Galectin-9; CD8; FOXp3; miR-455-5p
资金
- National Natural Science Foundation of China [81101917, 81270036, 30901736]
- Liaoning Province Natural Science Foundation [20170541022]
- Plan to Focus on Research and Development from Science and Technology project of Liaoning Province [2017225029]
- Science and Technology Plan Project of Shenyang City [18-014-4-11]
- Fund for Scientific Research of The First Hospital of China Medical University [FHCMU-FSR]
Chordoma is difficult to eradicate due to high local recurrence rates. The immune microenvironment is closely associated with tumor prognosis; however, its role in skull base chordoma is unknown. The expression of Galectin-9 (Gal9) and tumor-infiltrating lymphocyte (TIL) markers was assessed by immunohistochemistry. Kaplan-Meier and multivariate Cox analyses were used to assessing local recurrence-free survival (LRFS) and overall survival (OS) of patients. MiR-455-5p was identified as a regulator of Gal9 expression. Immunopositivity for Gal9 was associated with tumor invasion (p=0.019), Karnofsky performance status (KPS) score (p=0.017), and total TIL count (p<0.001); downregulation of miR-455-5p was correlated with tumor invasion (p=0.017) and poor prognosis; and the T-cell immunoglobulin and mucin-domain 3 (TIM3)(+) TIL count was associated with chordoma invasion (p=0.010) and KPS score (p=0.037). Furthermore, multivariate analysis indicated that only TIM3(+) TIL density was an independent prognostic factor for LRFS (p=0.010) and OS (p=0.016). These results can be used to predict clinical outcome and provide a basis for immune therapy in skull base chordoma patients.
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