期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 176, 期 23, 页码 4421-4433出版社
WILEY
DOI: 10.1111/bph.14790
关键词
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资金
- Talent Project of Zhejiang Association for Science and Technology [2018YCGC002]
- Zhejiang Provincial Natural Science Foundation [Y18H310005]
- National Natural Science Foundation of China [81872885]
Stress granules (SGs) are primarily composed of mRNAs that stall at translation initiation and usually appear in the cytoplasm under unusual physiological or pathological conditions such as hypoxia, oxidative stress, and viral infection. Recent studies have indicated that several components of SGs participate in tumourigenesis and cancer metastasis through tumour-associated signalling pathways as well as other mechanisms. Furthermore, some chemotherapy drugs have been reported to induce SGs. Thus, the roles of SGs in cancer treatment have attracted considerable interest. Importantly, disturbing the recruitment of SGs components or microtubule polymerization, as well as other strategies that can abolish SGs formation, is reported to inhibit tumour progression, suggesting that targeting SGs could be a promising strategy for cancer treatment. In this review, we summarize the relationship between SGs and cancer, as well as recent advances in targeting SGs, in the interest of providing new opportunities for cancer treatment.
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