期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 85, 期 -, 页码 106-119出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2019.06.029
关键词
Alcoholism; AQP4 polarization; A beta clearance; CSF-ISF exchange
资金
- Science and Technology Program of Guanzhou [2014J4500031]
- Macao Science and Technology Development Fund [020/2017/A1, 039/2017/AFJ]
- University of Macau [MYRG2016-00184-ICMS-QRCM, MYRG2018-00242-ICMS]
Alcoholism is a risk factor for the development of cognitive decline and dementia. Here we demonstrated that the glymphatic function in the brain was impaired by alcohol administration. Acute moderate alcohol administration substantially retarded and reduced the entry of subarachnoid cerebrospinal fluid (CSF) via the paravascular space into the cerebral parenchyma, thus impaired CSF-interstitial fluid (ISF) exchange and parenchymal amyloid beta (A beta) peptide clearance. The elevated release of beta-endorphin and reduced cerebrovascular pulsatility after acute alcohol administration may account for the impairment of the glymphatic function. Chronic moderate alcohol consumption led to pronounced activation of astrocytes and a widespread loss of perivascular AQP4 polarization in the brain, which results in an irreversible impairment of the glymphatic function. The results of the study suggest that impaired glymphatic functions and reduced parenchymal A beta clearance found in both acute and chronic alcohol treatment may contribute to the development of cognitive decline and dementia in alcoholism.
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