期刊
BIOMATERIALS
卷 53, 期 -, 页码 211-220出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.02.096
关键词
Magnesium alloy; Antibacterial properties; Biocompatibility; Corrosion; Biodegradable
资金
- Major Basic Research Project of Shanghai Science and Technology Commission [11DJ1400304, 12441903102]
- Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure [SKL201206SIC]
- National Natural Science Foundation of China [81271962, 81301571, 8111704]
Magnesium (Mg), a potential biodegradable material, has recently received increasing attention due to its Unique antibacterial property. However, rapid corrosion in the physiological environment and potential toxicity limit clinical applications. In order to improve the corrosion resistance meanwhile not compromise the antibacterial activity, a novel Mg alloy; Mg-Nd-Zn-Zr (Hereafter, denoted as JDBM), is fabricated by alloying with neodymium (Nd), zinc (Zn), zirconium (Zr). pH value, Mg ion concentration, corrosion rate and electrochemical test show that the corrosion resistance of JDBM is enhanced. A systematic investigation of the in vitro and in vivo antibacterial capability of JDBM is performed. The results of microbiological counting, CLSM, SEM in vitro, and microbiological cultures, histopathology in vivo consistently show JDBM enhanced the antibacterial activity. In addition, the significantly improved cytocompatibility is observed from JDBM. The results suggest that JDBM effectively enhances the corrosion resistance, biocompatibility and antimicrobial properties of Mg by alloying with the proper amount of Zn, Zr and Nd. (C) 2015 Elsevier Ltd. All rights reserved.
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