期刊
BMC PSYCHIATRY
卷 19, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12888-019-2184-6
关键词
Obsessive-compulsive disorder; Drug-naive; Resting-state fMRI; Fractional amplitude of low-frequency fluctuation; Multivariate classification; Support vector machine
类别
资金
- Sanming Project of Medicine in Shenzhen [SZSM201612006]
- Shenzhen Science and Technology Innovation Committee [JCYJ20180306171048616]
- National Natural Science Foundation of China [81671669, 81227002, 81220108013]
- Youth Technology Grant of Sichuan Province [2017JQ0001]
- Program for Changjiang Scholars and Innovative Research Team (PCSIRT) at the University of China [IRT1272]
BackgroundPrevious resting-state functional magnetic resonance imaging (rs-fMRI) studies have revealed intrinsic regional activity alterations in obsessive-compulsive disorder (OCD), but those results were based on group analyses, which limits their applicability to clinical diagnosis and treatment at the level of the individual.MethodsWe examined fractional amplitude low-frequency fluctuation (fALFF) and applied support vector machine (SVM) to discriminate OCD patients from healthy controls on the basis of rs-fMRI data. Values of fALFF, calculated from 68 drug-naive OCD patients and 68 demographically matched healthy controls, served as input features for the classification procedure.ResultsThe classifier achieved 72% accuracy (p <= 0.001). This discrimination was based on regions that included the left superior temporal gyrus, the right middle temporal gyrus, the left supramarginal gyrus and the superior parietal lobule.ConclusionsThese results indicate that OCD-related abnormalities in temporal and parietal lobe activation have predictive power for group membership; furthermore, the findings suggest that machine learning techniques can be used to aid in the identification of individuals with OCD in clinical diagnosis.
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