期刊
BIOMATERIALS
卷 42, 期 -, 页码 94-102出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.11.040
关键词
Photosensitizer; Sinoporphyrin sodium (DVDMS); Graphene oxide (GO); Photodynamic therapy; Fluorescence imaging
资金
- National Basic Research Program of China [2013CB733802, 2014CB744503, 2015CB931800, 2015CB931803]
- National Natural Science Foundation of China [81371596, 81401465, 81130028, 31210103913]
- Key Grant Project of Heilongjiang Province [GA12C302]
- Ph.D. Programs Foundation of Ministry of Education of China [201123071100203]
- Key Laboratory of Molecular Imaging Foundation(College of Heilongjiang Province)
- intramural research program of the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Extensive research indicates that graphene oxide (GO) can effectively deliver photosensitives (PSs) by pi-pi stacking for photodynamic therapy (PDT). However, due to the tight complexes of GO and PSs, the fluorescence of PSs are often drastically quenched via an energy/charge transfer process, which limits GO-PS systems for photodiagnostics especially in fluorescence imaging. To solve this problem, we herein strategically designed and prepared a novel photo-theranostic agent based on sinoporphyrin sodium (DVDMS) loaded PEGylated GO (GO-PEG-DVDMS) with improved fluorescence property for enhanced optical imaging guided PDT. The fluorescence of loaded DVDMS is drastically enhanced via intramolecular charge transfer. Meanwhile, the GO-PEG vehicles can significantly increase the tumor accumulation efficiency of DVDMS and lead to an improved PDT efficacy as compared to DVDMS alone. The cancer theranostic capability of the as-prepared GO-PEG-DVDMS was carefully investigated both in vitro and in vivo. Most intriguingly, 100% in vivo tumor elimination was achieved by intravenous injection of GO-PEG-DVDMS (2 mg/kg of DVDMS, 50 J) without tumor recurrence, loss of body weight or other noticeable toxicity. This novel GO-PEG-DVDMS theranostics is well suited for enhanced fluorescence imaging guided PDT. Published by Elsevier Ltd.
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