期刊
BIORESOURCE TECHNOLOGY
卷 281, 期 -, 页码 449-456出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2019.02.116
关键词
Terpenoids; Yarrowia lipolytica; Metabolic engineering; Mevalonate pathway
资金
- National Natural Science Foundation of China [21776131]
- Six Talent Peaks Project in Jiangsu Province of China [2018-SWYY-047]
- Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture [XTD1814]
Terpenoids are a large class of natural compounds based on the C5 isoprene unit, with many biological effects such activity against cancer and allergies, while some also have an agreeable aroma. Consequently, they have received extensive attention in the food, pharmaceutical and cosmetic fields. With the identification and analysis of the underlying natural product synthesis pathways, current microbial-based metabolic engineering approaches have yielded new strategies for the production of highly valuable terpenoids. Yarrowia lipolytica is a non-conventional oleaginous yeast that is rapidly emerging as a valuable host for the production of terpenoids due to its own endogenous mevalonate pathway and high oil production capacity. This review aims to summarize the status and strategies of metabolic engineering for the heterologous synthesis of terpenoids in Y. lipolytica in recent years and proposes new methods aiming towards further improvement of terpenoid production.
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