期刊
BIOORGANIC CHEMISTRY
卷 87, 期 -, 页码 728-735出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2019.03.078
关键词
Phomopsis lithocarpus; Deep-sea derived fungus; Tenellone derivatives; Lithocarols; Cytotoxicity
资金
- Science and Technology Program of Guangzhou, China [201607020018]
- Team Project of the Natural Science Foundation of Guangdong Province, China [2016A030312014]
- National Natural Science Foundation of China [31272087]
- Guangdong Provincial Innovative Development of Marine Economy Regional Demonstration Projects [GD2012-D01-002]
Lithocarols A-F (1-6) possessing novel highly-oxygenated isobenzofuran core, together with a related known compound isoprenylisobenzofuran A (7) were isolated from the marine-derived fungus Phomopsis lithocarpus FS508. Among them, lithocarols A-E (1-5) represent the first examples of poly-ketal derivatives in tenellone family. The structures for all these compounds were fully elucidated by spectroscopic analysis, X-ray diffraction, and electronic circular dichroism calculations. Their cytotoxic assay disclosed that compounds 1-4 displayed moderate growth inhibitory effect against four human tumor cell lines with the IC50 values ranging from 10.5 to 38.7 mu M.
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