期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 29, 期 16, 页码 2051-2058出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2019.06.013
关键词
miRNAs; IBD; CRC; CAC; miR-19a; miR-21; miR-31
资金
- National Natural Science Foundation of China [81872768, 81673323, 81473108]
- Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology [LMDBKF201701]
- young and middle-aged teachers' career development support plan of Shenyang Pharmaceutical University
- Liaoning Revitalization Talents Program [XLYC1807118]
- Liaoning BaiQianWan Talents Program
Colorectal cancer (CRC) is the third most malignant tumor. Inflammatory bowel disease (IBD) can increase the risk of colorectal cancer. And colitis-associated cancer (CAC) is a CRC subtype, representing the inflammation-related colorectal cancer. For the past decades, we have known that ectopic microRNA (miRNA) expression was involved in the pathogenesis of IBD and CRC, playing a pivotal role in the progression of inflammation to colorectal cancer. Thus, this review provides the recent advances in altered human tissue-specific miRNAs that contribute to IBD, CRC and CAC pathogenesis, diagnosis and treatment. Meanwhile, the potential utilization of miRNAs as novel therapeutic targets for the prevention of CRC was also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据