期刊
BIOMATERIALS
卷 205, 期 -, 页码 23-37出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2019.03.016
关键词
Dextran derivative sponge; Hemostasis; Tissue adhesion; Biodegradable
资金
- National Natural Science Foundation of China [21776038]
- International Science & Technology Cooperation Program of China [2015DFA41670]
Uncontrolled hemorrhage is closely related to the high risk of death. However, local hemostats still have various defects and side effects. Herein, an aldehyde dextran (PDA) sponge with proper absorption and adhesion properties is developed for hemorrhage control. PDA sponge with pore size of similar to 30-50 mu m fabricated by lyophilization not only absorbs blood quickly (47.7 g/g), but also possesses strong tissue adhesion (similar to 100 kPa). PDA sponge with low cytotoxicity and hemolysis achieves effective hemostasis and remarkable blood loss reduction in the ear vein, femoral artery and liver injuries of rabbit models. Furthermore, the exploration of hemostatic mechanisms related to tissue, blood, plasma, cells and coagulation system indicates that PDA sponge can significantly accelerate coagulation by rapid wound block, fast cells aggregation and initiation, and high coagulation factors concentration, instead of by the coagulation cascade activation. Importantly, this hemostat exhibits excellent biodegradability and nearly no skin irritation. Overall, the biodegradable and tissue adhesive PDA sponge will be a promising quick-hemostatic dressing for uncontrollable hemorrhage.
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