期刊
BIOMARKERS IN MEDICINE
卷 13, 期 8, 页码 639-648出版社
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2018-0351
关键词
clusterin; immune-inflammatory biomarkers; MMF; repeated measures design; reproducibility; suPAR; TGF-beta
资金
- German Institute of Human Nutrition Potsdam-Rehbrucke
Aim: Assessment of the feasibility and reliability of immune-inflammatory biomarker measurements. Methods: The following biomarkers were assessed in 207 predominantly healthy participants at baseline and after 4 months: MMF, TGF-beta, suPAR and clusterin. Results: Intraclass correlation coefficients (95% CIs) ranged from good for TGF-beta (0.75 [95% CI: 0.33-0.90]) to excellent for MMF (0.81 [95% CI: 0.64-0.90]), clusterin (0.83 [95% CI: 0.78-0.87]) and suPAR (0.91 [95% CI: 0.88-0.93]). Measurement of TGF-beta was challenged by the large number of values below the detection limit. Conclusion: Single measurements of suPAR, clusterin and MMF could serve as feasible and reliable biomarkers of immune-inflammatory pathways in biomedical research.
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