Decreased S1P and SPHK2 are involved in pancreatic acinar cell injury

Aim: The roles of S1P in acute pancreatitis (AP) or non-AP patients with pancreatic acinar cell injury (PACI) are not well understood. Materials & methods: Serum S1P, in 40 healthy individuals and 99 patients with PACI, was retrospectively analyzed. Additionally, we detected and analyzed S1P in AP mice and the AR42J acinar cell line. Results: Serum S1P was significantly decreased in PACI patients, compared with that of healthy controls. Patients with gall stones, normal serum calcium or normal blood lipids showed relative higher levels of serum S1P. Interestingly, in patients with gall or liver disease, serum S1P was positively associated with gamma-GT and ALT. Additionally, S1P and SPHK2 were decreased in AP mice and AR42J cells, relative to the levels of corresponding controls. Conclusion: Serum S1P is decreased in PACI, which may be partly due to downregulation of pancreatic SPHK2.