期刊
BIOLOGICAL REVIEWS
卷 94, 期 6, 页码 2033-2048出版社
WILEY
DOI: 10.1111/brv.12547
关键词
Ase1; PRC1; anaphase; central spindle; cytokinesis; microtubule; midzone
类别
资金
- Natural Science Foundation of Fujian Province, China [2019J05071]
- Health and Family Planning Commission of Fujian Province [2018-1-69]
- Startup Fund for scientific research, Fujian Medical University [2017XQ1001]
- Fujian Medical University high-level talents scientific research start-up funding project [XRCZX2017025]
During cytokinesis, the organization of the spindle midzone and chromosome segregation is controlled by the central spindle, a microtubule cytoskeleton containing kinesin motors and non-motor microtubule-associated proteins. The anaphase spindle elongation 1/protein regulator of cytokinesis 1/microtubule associated protein 65 (Ase1/PRC1/MAP65) family of microtubule-bundling proteins are key regulators of central spindle assembly, mediating microtubule crosslinking and spindle elongation in the midzone. Ase1/PRC1/MAP65 serves as a complex regulatory platform for the recruitment of other midzone proteins at the spindle midzone. Herein, we summarize recent advances in understanding of the structural domains and molecular kinetics of the Ase1/PRC1/MAP65 family. We summarize the regulatory network involved in post-translational modifications of Ase1/PRC1 by cyclin-dependent kinase 1 (Cdk1), cell division cycle 14 (Cdc14) and Polo-like kinase 1 (Plk1) and also highlight multiple functions of Ase1/PRC1 in central spindle organization, spindle elongation and cytokinesis during cell division.
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