期刊
BIOINFORMATICS
卷 35, 期 22, 页码 4767-4769出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btz456
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资金
- EU-FP7 project EpiTrain [316758]
- Wellcome Trust [99148]
- Royal Society Wolfson Research Merit Award [WM100023]
- EU-FP7 project EPIGENESYS [257082]
- EU-FP7 project BLUEPRINT [282510]
The Summary: The Illumina Infinium EPIC BeadChip is a new high-throughput array for DNA methylation analysis, extending the earlier 450k array by over 400 000 new sites. Previously, a method named eFORGE was developed to provide insights into cell type-specific and cell-composition effects for 450k data. Here, we present a significantly updated and improved version of eFORGE that can analyze both EPIC and 450k array data. New features include analysis of chromatin states, transcription factor motifs and DNase I footprints, providing tools for epigenome-wide association study interpretation and epigenome editing.
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