期刊
BIOESSAYS
卷 41, 期 7, 页码 -出版社
WILEY
DOI: 10.1002/bies.201800227
关键词
adherens junctions; epithelial cells; tight junctions
资金
- Japan Society for the Promotion of Science KAKENHI [JP17H06012, JP19H03227, JP19H04968, JP17J00211]
- Japan Agency for Medical Research and Development-PRIME [15664862]
- Japan Science and Technology Corporation-Precursory Research for Embryonic Science and Technology [JPMJPR12A4]
- MSD Life Science Foundation
- Takeda Science Foundation
- Japan Society for the Promotion of Science Research Fellowship for Young Scientists [DC1]
There are many morphologically distinct membrane structures with different functions at the surface of epithelial cells. Among these, adherens junctions (AJ) and tight junctions (TJ) are responsible for the mechanical linkage of epithelial cells and epithelial barrier function, respectively. In the process of new cell-cell adhesion formation between two epithelial cells, such as after wounding, AJ form first and then TJ form on the apical side of AJ. This process is very complicated because AJ formation triggers drastic changes in the organization of actin cytoskeleton, the activity of Rho family of small GTPases, and the lipid composition of the plasma membrane, all of which are required for subsequent TJ formation. In this review, the authors focus on the relationship between AJ and TJ as a representative example of specialization of plasma membrane regions and introduce recent findings on how AJ formation promotes the subsequent formation of TJ.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据