期刊
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
卷 189, 期 4, 页码 1291-1303出版社
SPRINGER
DOI: 10.1007/s12010-019-03067-1
关键词
Ainsliaea bonatii; Hydroquinone; Arbutin; Antibacterial mechanism; Staphylococcus aureus
资金
- Ministry of Science and Technology of the People's Republic of China [2017YFC1601400]
- Scientific and Technology Department of Henan Province [182102110332]
With growing concern about the possible risks and side effects of antibiotic drugs, more and more natural products with antibacterial activity are studied as the substitutes. In this paper, the antibacterial activity of hydroquinone and arbutin in Ainsliaea bonatii was investigated, which both displayed relatively strong antibacterial activity against Staphylococcus aureus (SA), methicillin-resistant S. aureus (MRSA), and extended spectrum beta-lactamase S. aureus (ESBL-SA). The antibacterial mechanism of hydroquinone had been explored by scanning electron microscopy (SEM), alkaline phosphatase (AKP), and bacterial extracellular protein leakage. Results showed that hydroquinone could destroy the bacterial cell wall and membrane, increase permeability, lead leakage of intracellular substance affect synthesis of protein, and influence expression of genes.
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