期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 63, 期 8, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00769-19
关键词
repurposing; antibiotic resistance breakers; antimicrobial combinations
资金
- MRC [MR/N002679/1, G0400848, MR/S014934/1] Funding Source: UKRI
The Prestwick library was screened for antibacterial activity or 'antibiotic resistance breaker (ARB) potential against four species of Gram-negative pathogens. Discounting known antibacterials, the screen identified very few ARB hits, which were strain/drug specific. These ARB hits included antimetabolites (zidovudine, floxuridine, didanosine, and gemcitabine), anthracyclines (daunorubicin, mitoxantrone, and epirubicin), and psychoactive drugs (gabapentin, fluspirilene, and oxethazaine). These findings suggest that there are few approved drugs that could be directly repositioned as adjunct antibacterials, and these will need robust testing to validate efficacy.
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