期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35
卷 35, 期 -, 页码 477-500出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-100818-125242
关键词
autophagy; mitophagy; ERphagy; aggrephagy; neuronal homeostasis; neurodegeneration
资金
- NINDS NIH HHS [R37 NS060698, K99 NS109286] Funding Source: Medline
Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein aggregates. Autophagy is particularly important in neurons, which are terminally differentiated cells that must last the lifetime of the organism. There are both constitutive and stress-induced pathways for autophagy in neurons, which catalyze the turnover of aged or damaged mitochondria, endoplasmic reticulum, other cellular organelles, and aggregated proteins. These pathways are required in neurodevelopment as well as in the maintenance of neuronal homeostasis. Here we review the core components of the pathway for autophagosome biogenesis, as well as the cell biology of bulk and selective autophagy in neurons. Finally, we discuss the role of autophagy in neuronal development, homeostasis, and aging and the links between deficits in autophagy and neurodegeneration.
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