期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88
卷 88, 期 -, 页码 307-335出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-013118-111042
关键词
translation; ribosome recruitment; eukaryotic initiation factors; eIF4F; eIF4E; eIF4A; eIF4G; eIF4B; eIF4H
资金
- CIHR Funding Source: Medline
The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is positioned at an appropriate initiation codon and primed to synthesize the encoded polypeptide product. In most circumstances, this step commits the ribosome to translate the mRNA. We summarize the knowledge regarding the initiation factors implicated in this activity as well as review different mechanisms by which this process is conducted.
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