4.7 Editorial Material

The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors

期刊

出版社

WILEY
DOI: 10.1111/nyas.14094

关键词

adhesion G protein-coupled receptor; structural biology; signal transduction; mechanosensation; development; neurobiology; immunology; cancer

资金

  1. Oregon Health & Science University (OHSU)
  2. Vollum Institute at OHSU
  3. University of Illinois at Chicago
  4. Rudolf Schonheimer Institute of Biochemistry
  5. Tecniplast
  6. Union Biometrica
  7. Zeiss
  8. NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [ZIAAA000284] Funding Source: NIH RePORTER

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The adhesion class of G protein-coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound to the 7TM of the C-terminal fragment (CTF). The NTFs of most aGPCRs contain domains known to be involved in cell-cell adhesion, while the CTFs are involved in classical G protein signaling, as well as other intracellular signaling. In this workshop report, we review the most recent findings on the biology, signaling mechanisms, and physiological functions of aGPCRs.

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