期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 40, 页码 14055-14064出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201905532
关键词
atom efficiency; carbonyl addition; enantioselectivity; hydrogenation; total synthesis
资金
- Welch Foundation [F-0038]
- NIH [R01 GM093905]
Use of abundant feedstock pronucleophiles in catalytic carbonyl reductive coupling enhances efficiency in target-oriented synthesis. For such reactions, equally inexpensive reductants are desired or, ideally, corresponding hydrogen autotransfer processes may be enacted wherein alcohols serve dually as reductant and carbonyl proelectrophile. As described in this Minireview, these concepts allow reactions that traditionally require preformed organometallic reagents to be conducted catalytically in a byproduct-free manner from inexpensive pi-unsaturated precursors.
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