期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 38, 页码 13448-13451出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201907758
关键词
aza-Heck reaction; catalysis; cyclization; indolines; palladium
资金
- University of Delaware (UD)
- NIH NIGMS [NIH P20 GM104316]
- NIH [NIH P20 GM104316, P20 GM104316, P30 GM110758, S10 RR026962, S10 OD016267, NSF CHE-0421224, CHE-0840401, CHE-1229234, CHE-1048367]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P30GM110758, P20GM104316] Funding Source: NIH RePORTER
For the first time, an aza-Heck cyclization that allows the preparation of indoline scaffolds is described. Using N-hydroxy anilines as electrophiles, which can be easily accessed from the corresponding nitroarenes, this method provides indolines bearing pendant functionality and complex ring topologies. Synthesis of challenging indolines, such as those bearing fully substituted carbon atoms at C2, is also possible using this method.
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