期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 35, 页码 12223-12230出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201904598
关键词
Forster resonance energy transfer; hierarchical assembly; micelles; membranes; peptoids
资金
- Materials Synthesis and Simulation Across Scales (MS3) Initiative through the Laboratory Directed Research and Development program at Pacific Northwest National Laboratory (PNNL)
- U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Science and Engineering, Biomolecular Materials Program
- Department of Energy [DE-AC05-76RL01830]
Herein we show that by appending bulky beta-cyclodextrin (CD) groups onto sheet-forming peptoids, we obtain cylindrical micelles that further assembly into membranes and intertwined ribbons on substrates in aqueous solution, depending on the choice of solution and substrate conditions. In situ atomic force microscopy (AFM) shows that micelle assembly occurs in two steps, starting with precursor particles that transform into worm-like micelles, which extend and coalesce to form the higher order structures with a rate and a degree of cooperativity dependent on pH and Ca2+ concentration. After co-assembly with hydrophobic 4-(2-hydroxyethylamino)-7-nitro-2,1,3-benzoxadiazole (NBD) donors that occupy the hydrophobic core, followed by exposure to hydrophilic Rhodamine B as acceptors that insert into cyclodextrin, the micelles exhibit highly efficient Forster resonance energy transfer efficiency in aqueous solution, thereby mimicking natural light harvesting systems.
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