期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 34, 页码 14212-14233出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201906823
关键词
biomedical applications; sonodynamic therapy; sonosensitizers; theranostics; ultrasound imaging
资金
- National Natural Science Foundation of China [U1505221, 21874024]
- Program for Changjiang Scholars and the Innovative Research Team in University [IRT15R11]
- Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (NIH)
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [ZIAEB000073] Funding Source: NIH RePORTER
Modalities for photo-triggered anticancer therapy are usually limited by their low penetrative depth. Sonotheranostics especially sonodynamic therapy (SDT), which is different from photodynamic therapy (PDT) by the use of highly penetrating acoustic waves to activate a class of sound-responsive materials called sonosensitizers, has gained significant interest in recent years. The effect of SDT is closely related to the structural and physicochemical properties of the sonosensitizers, which has led to the development of new sound-activated materials as sonosensitizers for various biomedical applications. This Review provides a summary and discussion of the types of novel sonosensitizers developed in the last few years and outlines their specific designs and the potential challenges. The applications of sonosensitizers with various functions such as for imaging and drug delivery as well as in combination with other treatment modalities would provide new strategies for disease therapy.
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