期刊
APPLIED CLAY SCIENCE
卷 130, 期 -, 页码 20-32出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.clay.2016.01.021
关键词
Clay; Drug delivery carrier; Controlled and sustained release; Nanohybrid
Biocompatible 2-dimensional layered compounds such as clays and layered double hydroxides (anionic clays) have been explored and utilized in drug delivery system for therapeutic application because they can safely encapsulate drug molecules via intercalation reaction. Therefore, various kinds of drug molecules and bio-functional molecules with cationic or anionic charge have been incorporated into clay delivery carriers, giving rise to the heterostructured layered nanohybrids with chemo-therapeutic and gene-therapeutic functions. Recently, such inorganic delivery systems have received growing attention because their inertness and low toxicity gives rise to safety and stability in bio-systems. Furthermore, the hybridization of drug with clays offers the fascinating features such as controlled and sustained release, improved water-solubility, and even protective and targeted delivery. Unique release behaviors of drugs from the drug-clay nanohybrids are originated from molecular level incorporation, and strong interaction between drug and inorganic layers including electrostatic and hydrogen bonding interactions. In the present review, various drug-clay nanohybrids will be introduced, and their recent development will be highlighted in the viewpoint of oral administration drugs with controlled and sustained release. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据