期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 38, 页码 13405-13410出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201908377
关键词
germanene; multimodal imaging; photothermal therapy; quantum dots; 2D materials
资金
- U.S. METAvivor Early Career Investigator Award [2018A020560]
- National Natural Science Foundation of China [81672932, 81730108, 81874380]
- Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars [LR18H160001]
- Zhejiang Province Science and Technology Project of TCM [2019ZZ016]
- Harvard Medical School/Brigham and Women's Hospital Department of Anesthesiology-Basic Scientist Grant [2420 BPA075]
As a new family member of the emerging two-dimensional (2D) monoelemental materials (Xenes), germanene has shown promising advantages over the prototypical 2D Xenes, such as black phosphorus (BP) and graphene. However, efficient manufacture of novel germanene nanostructures is still a challenge. Herein, a simple top-down approach for the liquid-exfoliation of ultra-small germanene quantum dots (GeQDs) is presented. The prepared GeQDs possess an average lateral size of about 4.5 nm and thickness of about 2.2 nm. The functionalized GeQDs were demonstrated to be robust photothermal agents (PTAs) with outstanding photothermal conversion efficacy (higher than those of graphene and BPQDs), superior stability, and excellent biocompatibility. As a proof-of-principle, 2D GeQDs-based PTAs were used in fluorescence/photoacoustic/photothermal-imaging-guided hyperpyrexia ablation of tumors. This work could expand the application of 2D germanene to the field of photonic cancer nanomedicine.
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