期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 37, 页码 13030-13034出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201906462
关键词
cross-coupling; flow chemistry; iron catalysis; Kumada coupling; photocatalysis
资金
- European Union [641861, 794072]
- Engineering and Physical Sciences Research Council [EP/M02105X/1]
- EPSRC [EP/M02105X/1] Funding Source: UKRI
- Marie Curie Actions (MSCA) [794072] Funding Source: Marie Curie Actions (MSCA)
A continuous-flow, visible-light-promoted method has been developed to overcome the limitations of iron-catalyzed Kumada-Corriu cross-coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes' residence time, considerably enhancing the applicability of this iron-catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application.
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