期刊
ANALYTICAL SCIENCES
卷 35, 期 6, 页码 625-630出版社
JAPAN SOC ANALYTICAL CHEMISTRY
DOI: 10.2116/analsci.18P576
关键词
Conjugated polymer; fluorescence sensor; Cu2+; pyrophosphate; synovial fluid; blood serum
资金
- State Major Project for Science and Technology Development, China [2013YQ47078102-3]
- Science -Technology Development Project of Jilin Province of China [20150204060GX]
- Natural Science Foundation of Jilin Province [20160101314JC]
A novel on-off-on super-sensitive conjugated polymer fluorescence sensor (PPE-DPA) was developed and it was applied to realize the continuous recognition of Cu2+ and pyrophosphate (PPi). The fluorescence intensity decreased linearly with the change of Cu2+ from 0.05 to 5.0 mu mol L-1 and the limit of detection was 24 nmol L-1. The fluorescence intensity was linearly enhanced with the increase of PPi from 0.5 to 12.0 mu mol L-1 and the limit of detection was 230 nmol L-1. In addition, this method was applied to detect PPi in the blood serum and synovial fluid of patients with arthritis and satisfactory results were obtained. Thus, the PPE-DPA is not only an effective tool for detecting Cu2+ and PPi in samples, but also presents a potential way to diagnose arthritis.
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