期刊
ANALYTICAL SCIENCES
卷 35, 期 6, 页码 609-618出版社
JAPAN SOC ANALYTICAL CHEMISTRY
DOI: 10.2116/analsci.19R001
关键词
Microfluidics; single-cell analysis; in vitro; ex vivo; in vivo
资金
- National Natural Science Foundation of China [31870856, 31870854, 21775049, 31700746]
- National Key RAMP
- D Program of China [2016YFF0100801, 2017YFA0700403]
- China Postdoctoral Science Foundation [2018T110753, 2018M630847]
A microfluidic device as a pivotal research tool in chemistry and life science is now widely recognized. Indeed, microfluidic techniques have made significant advancements in fundamental research, such as the inherent heterogeneity of single-cells studies in cell populations, which would be helpful in understanding cellular molecular mechanisms and clinical diagnosis of major diseases. Single-cell analyses on microdevices have shown great potential for precise fluid control, cell manipulation, and signal output with rapid and high throughput. Moreover, miniaturized devices also have open functions such as integrating with traditional detection methods, for example, optical, electrochemical or mass spectrometry for single-cell analysis. In this review, we summarized recent advances of single-cell analysis based on various microfluidic approaches from different dimensions, such as in vitro, ex vivo, and in vivo analysis of single cells.
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