期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 317, 期 3, 页码 E446-E459出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00140.2019
关键词
Akkermansia muciniphila; bariatric surgery; dysbiosis; gut microbiota; severe obesity
资金
- Programme Hospitalier de Recherche Clinique [MicroBaria AOM10285/P100111]
- Alliance Nationale pour les Sciences de la Vie et de la Sante
- Institut Thematique Multi-organismes Sante Publique
- Institut Appert
- Nestle Research
- Danone Nutricia Research
- European Union's Seventh Framework Programme for research, technological development, and demonstration [HEALTH-F4-2012-305312]
- French national program Investissement d'Avenir French Obesity Research Center of Excellence, MetaGenoPolis Grant [ANR-11-DPBS-0001]
- Institute of Cardiometabolism and Nutrition [ICAN] [ANR-10-IAHU-05]
- Fonds Baillet Latour (Grant for Medical Research 2015)
- prize Banque Transatlantique Belgium,
- European Research Council starting grant [336452-ENIGMO]
The gut bacterial species Akkermansia muciniphila is associated with a healthier clinical profile. The purpose of this study was to determine the association between A. muciniphila and glucose homeostasis in patients undergoing bariatric surgery (BS): gastric banding (GB) or Roux-en-Y gastric bypass (RYGB). This nonrandomized prospective study included 65 women with severe obesity. Longitudinal analysis included subjects for whom A. muciniphila data were available at follow-up [1, 3, and 12 mo; GB (n = 10) or RYGB (n = 11)]. Glucose homeostasis markers were measured under fasting conditions (glucose. insulin, and HbAlc) or during an oral glucose tolerance test. Fecal microbiota was analyzed using shotgun metagenomics, and A. muciniphila relative abundance was assessed with 16S rRNA quantitative PCR. A. muciniphila relative abundance was significantly lower in severe obesity [mean body mass index. 45.7 kg/m(2) (SD 5.4)] than in moderate obesity [33.2 kg/m(2) (SD 3.8)] but not associated with glucose homeostasis markers. A significant increase in A. muciniphila relative abundance after RYGB was not correlated with metabolic improvement. Baseline A. muciniphila abundance was correlated with bacterial gene richness and was highest in the high-richness Ruminococcaceae enterotype. A. muciniphila increased in relative abundance after BS in patients with low baseline A. muciniphila abundance, especially those with a Bacteroides type 2 enterotype classification. Although decreased in severe obesity, relative abundance of A. muciniphila was not associated with glucose homeostasis before or after BS. A certain level of A. muciniphila abundance might be required to observe a beneficial link to health. The severity of obesity and gut dysbiosis may partly explain the discrepancy with previous findings in less obese populations.
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