期刊
AMERICAN JOURNAL OF HYPERTENSION
卷 32, 期 11, 页码 1101-1108出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajh/hpz106
关键词
adiponectin; Africa; blood pressure; BMI; hypertension; leptin; lithium clearance; sex; sodium excretion
资金
- Swiss National Fund (SNF) [PZ00P3_137262, Ambizione PZ00P3_121655]
- Fonds De La Recherche Scientifique FNRS [PZ00P3_137262, Ambizione PZ00P3_121655, PROSPER 3200BO-111362/1, 3233BO-111361/1, TANDEM 31-51115.97]
- Swiss National Science Foundation (SNF) [PZ00P3_137262] Funding Source: Swiss National Science Foundation (SNF)
BACKGROUND Renal sodium handling could be a potential mediator linking adipokines to hypertension. The aim of the study was to assess the relationship of leptin with urinary sodium excretion and proximal sodium reabsorption in humans. METHODS This cross-sectional study was conducted on participants of hypertensive families from the Seychelles Island. A split urine (daytime and nighttime) collection and plasma leptin were measured. Endogenous lithium clearance was used to assess proximal sodium reabsorption. Mixed multiple linear regression tests adjusted for confounding factors were used. RESULTS Three hundred and sixty-five participants (57% women) were included in this analysis. Leptin and adiponectin were higher in women (P < 0.001). Leptin was associated positively with daytime (coefficient [c]: 0.16, standard deviation (SD): 0.03, P < 0.001), nighttime urinary sodium excretion (c: 0.17, SD: 0.04), P < 0.01), daytime lithium clearance (c: 0.40, SD: 0.08, P < 0.001), and nighttime lithium clearance (c: 0.39, SD: 0.10, P < 0.001) after adjusting for sex. The association was lost or mitigated only when BMI was introduced in the model. When BMI was categorized in normal vs. overweight participant, leptin was associated with daytime and nighttime sodium excretion rates (c: 0.14, SD: 0.05, P = 0.011 and c: 0.22, SD: 0.07, P = 0.002, respectively) only in overweight participants. CONCLUSION Leptin is associated positively with daytime and nighttime sodium excretion and lithium clearance suggesting a natriuretic rather than a sodium retaining effect of leptin. Sex and body mass index (BMI) are major confounders in this association. These results highlight the importance of sex and obesity in our understanding of the relationships between leptin, blood pressure, and renal sodium handling.
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