期刊
ALZHEIMERS & DEMENTIA
卷 15, 期 7, 页码 927-939出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2019.03.016
关键词
Autopsy; Braak tangle stage; CERAD; Thal amyloid stage; Dementia; Alzheimer's disease; Mild cognitive impairment; Tau-PET; Amyloid-PET; MRI; Amyloid; Neurodegeneration; SNAP
资金
- Mangurian Foundation
- Robert H. and Clarice Smith and Abigail vanBuren AD Research Program
- Elsie and Marvin Dekelboum Family Foundation
- NIH [P50 AG016574, R01 NS89757, R01 NS089544, R01 DC10367, R01-AG054449, U01 AG006786, R21 NS094489]
- Robert Wood Johnson Foundation
- Lefkofsky Family Foundation
- Robert H. and Clarice Smith and Abigail van Buren Alzheimer's Disease Research Program
- GHR Foundation
- Mayo Foundation
- [R01-AG040042]
- [R01-AG011378]
- [R01-AG041851]
- [P50-AG016574/P1]
- [U01-AG006786]
- NATIONAL INSTITUTE ON AGING
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS089757] Funding Source: NIH RePORTER
Introduction: Neuroimaging biomarkers are important for early diagnosis of Alzheimer's disease, and comparing multimodality neuroimaging to autopsy data is essential. Methods: We compared the pathologic findings from a prospective autopsy cohort (n = 100) to Pittsburgh compound B PET (PiB-PET), F-18-fluorodeoxyglucose PET (FDG-PET), and MRI. Correlations between neuroimaging biomarkers and neuropathologic schemes were assessed. Results: PiB-PET showed strong correlations with Thal amyloid phase and Consortium to Establish a Registry for Alzheimer's Disease score and categorized 44% of Thal phase 1 participants as positive. FDG-PET and MRI correlated modestly with Braak tangle stage in Alzheimer's type pathology. A subset of participants with none or sparse neuritic plaque scores had elevated PiB-PET signal due to diffuse amyloid plaque. Participants with findings characterized as suspected non-Alzheimer's pathophysiology represented 15% of the group. Discussion: PiB-PET is associated with Alzheimer's disease, neuritic plaques, and diffuse plaques. FDG-PET and MRI have modest correlation with neuropathologic schemes. Participants with findings characterized as suspected non-Alzheimer's pathophysiology most commonly had primary age-related tauopathy. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据