期刊
AGING-US
卷 11, 期 14, 页码 5070-5080出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.102098
关键词
vegetarian; telomere length; carotid intima-media thickness; cardiovascular
资金
- National Council for Scientific and Technological Development (CNPq) [2014-5/305587]
- Sao Paulo Research Foundation (FAPESP-Brazil) [2015/20669-8]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Foundation for Research of the State of Minas Gerais (FAPEMIG)
Telomere length is considered to be a biomarker of biological aging and age-related disease. There are few studies that have evaluated the association between telomere length and diet, and none of them have evaluated the impact of a vegetarian diet on telomere length and its correlation with cardiovascular biomarkers in apparently healthy subjects. Therefore, our objectives were to evaluate leukocyte telomere length (LTL) in vegetarians and omnivorous subjects and its association with classical cardiovascular risk biomarkers. From the total of 745 participants initially recruited, 44 omnivorous and 44 vegetarian men apparently healthy were selected for this study and LTL was measured in 39 omnivorous and 41 vegetarians by Real-Time Quantitative PCR reaction. Although telomere length was not different between omnivorous and vegetarians, we found a strong negative correlation between LTL and IMT (intima-media thickness) in omnivorous, but not in vegetarian group. In addition, omnivorous who were classified with short telomere length had higher carotid IMT compared to vegetarians. Our data suggest that telomere length can be a marker of subclinical atherosclerosis in the omnivorous group.
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