Visible-Light-Promoted Transition-Metal-Free Approach toward Phosphoryl-Substituted Dihydroisoquinolones via Cascade Phosphorylation/Cyclization of N-Allylbenzamides

A transition-metal-free visible-light-promoted radical phosphorylation/cyclization of N-allylbenzamides with phosphine oxides for the synthesis of phosphoryl-substituted dihydroisoquinolones was developed under room temperature. This protocol features mild reaction conditions, simple operation, broad substrate scope as well as scale-up ability.