期刊
ADVANCED MATERIALS
卷 31, 期 30, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201902504
关键词
cerebrovascular structures; early-stage brain tumors; fluorescence and photoacoustic imaging; focused ultrasound; second near-infrared window
类别
资金
- Singapore NRF Competitive Research Program [R279-000-483-281]
- Natural Science Foundation of China [81571745, 81401521, 91859117, 81771906, 61735016]
- National University of Singapore [R279-000-482-133]
- NRF Investigatorship [R279-000-444-281]
- Zhejiang Provincial Natural Science Foundation of China [LR17F050001]
- National Key Research and Development Program of China [2017YFE0120000]
- Science and Technology Innovation Fund of Shenzhen [JCYJ20170818161918918]
- Shenzhen Key Laboratory of Ultrasound Imaging and Therapy [ZDSYS201802061806314]
- Shenzhen Double Chain Grant [[2018] 256]
- Natural Science Foundation of Guangdong Province [2014A030312006]
Diagnostics of cerebrovascular structures and microscopic tumors with intact blood-brain barrier (BBB) significantly contributes to timely treatment of patients bearing neurological diseases. Dual NIR-II fluorescence and photoacoustic imaging (PAI) is expected to offer powerful strength, including good spatiotemporal resolution, deep penetration, and large signal-to-background ratio (SBR) for precise brain diagnostics. Herein, biocompatible and photostable conjugated polymer nanoparticles (CP NPs) are reported for dual-modality brain imaging in the NIR-II window. Uniform CP NPs with a size of 50 nm are fabricated from microfluidics devices, which show an emission peak at 1156 nm with a large absorptivity of 35.2 L g(-1) cm(-1) at 1000 nm. The NIR-II fluorescence imaging resolves hemodynamics and cerebral vasculatures with a spatial resolution of 23 mu m at a depth of 600 mu m. The NIR-II PAI enables successful noninvasive mapping of deep microscopic brain tumors (<2 mm at a depth of 2.4 mm beneath dense skull and scalp) with an SBR of 7.2 after focused ultrasound-induced BBB opening. This study demonstrates that CP NPs are promising contrast agents for brain diagnostics.
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