期刊
ADVANCED FUNCTIONAL MATERIALS
卷 29, 期 36, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201904056
关键词
Fenton reaction; glutathione; manganese superoxide dismutase; metal-organic nanostructures; sonodynamic therapy
类别
资金
- Major State Basic Research Development Program of China [2017YFA0205201, 2016YFC0106900]
- National Natural Science Foundation of China (NSFC) [81422023, 81801817, 81603015, U1705281, U1505221]
- Fundamental Research Funds for the Central Universities [20720190088]
- Program for New Century Excellent Talents in University, China [NCET-13-0502]
- China Postdoctoral Science Foundation [K6419001]
- Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials
To address the urgent need for effective sonodynamic therapy (SDT), a facile and efficient strategy is developed for fabricating a new class of sonotheranostics. Herein, a Fe(III)-porphyrin nano-sonosensitizer is prepared by a one-step coordination synthesis, and then anchored with Bis(DPA-Zn)-RGD and manganese superoxide dismutase (SOD2) siRNA. Benefiting from the delicate interactions of the Fe(III)-coordinated nanoformulations, a highly potent sono/gene combinational therapy guided by fluorescence/magnetic resonance imaging is achieved. Importantly, this sonotheranostics significantly enhances the SDT effect of porphyrin through the cancer-targeted delivery capability and enhanced reactive oxygen species production via triple-regulated approaches, including down-regulation of SOD2, depletion of glutathione, and generation of Fenton reaction. This work opens up new perspectives for developing versatile sonotheranostics to overcome the clinical challenges of SDT.
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