期刊
ACS NANO
卷 13, 期 7, 页码 7556-7567出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b00097
关键词
breast cancer bone metastasis; mesoporous silica nanoparticles; bone target; zoledronate; photothermal therapy
类别
资金
- National Natural Science Foundations of China [31470961, 21807023, 31500812]
- Basic Research Foundation of Education Ministry of Hebei Province [QN2018010]
- Natural Science Key Foundation of Hebei Province [B2017201226]
- Natural Science Foundation of Hebei Province [B2017201135]
Bone metastasis, a clinical complication of patients with advanced breast cancer, seriously reduces the quality of life. To avoid destruction of the bone matrix, current treatments focus on inhibiting the cancer cell growth and the osteoclast activity through combination therapy. Therefore, it could be beneficial to develop a bone-targeted drug delivery system to treat bone metastasis. Here, a bone-targeted nanoplatform was developed using gold nanorods enclosed inside mesoporous silica nanoparticles (Au@MSN5) which were then conjugated with zoledronic acid (ZOL). The nanoparticles (Au@MSNs-ZOL) not only showed bone-targeting ability in vivo but also inhibited the formation of osteoclast-like cells and promoted osteoblast differentiation in vitro. The combination of Au@MSNs-ZOL and photothermal therapy (PTT), triggered by near-infrared irradiation, inhibited tumor growth both in vitro and in vivo and relieved pain and bone resorption in vivo by inducing apoptosis in cancer cells and improving the bone microenvironment. This single nanoplatform combines ZOL and PTT to provide an exciting strategy for treating breast cancer bone metastasis.
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