期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 33, 页码 29681-29688出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b11957
关键词
photo responsive; cell release; photo-irresponsive; spiropyran; nanostructure
资金
- National Key R&D Program of China [2018YFC1105301]
- National Natural Science Foundation of China [21875269, 21425314]
- Youth Innovation Promotion Association CAS [2017036]
- National Program for Special Support of Eminent Professionals
Cell manipulation has raised extensive concern owing to its underlying applications in numerous biological situations such as cell-matrix interaction, tissue engineering, and cell-based diagnosis. Generally, light is considered as a superior candidate for manipulating cells (e.g., cell release) due to their high spatiotemporal precision and non-invasion. However, it remains a big challenge to release cells with high efficiency due to their potential limitation of the light-triggered wettability transition on photoresponsive surfaces. In this study, we report a photoresponsive spiropyran-coated nanostructured surface that enables highly efficient release of cancer cells, amplified by the introduction of a photo-irresponsive molecule. On one hand, structural recognition stems from topological interaction between nanofractal surfaces and the protrusions of cancer cells. On the other, molecular recognition can be amplified by a photo-irresponsive and hydrophilic molecule by reducing the steric hindrance of photoresponsive components and resisting nonspecific cell adhesion. Therefore, this study may afford a novel avenue for developing advanced smart materials for high-quality biological analysis and clinical diagnosis.
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